Addison's disease

Addison's disease, progressive disease resulting from atrophy of the cortex (outer layer) of the adrenal glands. Deficient secretion of the hormones aldosterone or cortisol causes lowered blood volume and pressure, anemia, low blood sugar, gastrointestinal upsets, and brownish pigmentation of the skin. The cause is unknown. The disease, which occurs in all age groups and in both sexes, is often successfully treated today with adrenocortical hormones, reversing its previously fatal effects.

See also: Gland.